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Clinical outcomes of stents versus balloon angioplasty in non-acute coronary artery disease. A meta-analysis of randomized controlled trials.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nordmann, Alain J. Hengstler, Peter M. Leimenstoll, Bernd M. Harr, Thomas C. Young, James Bucher, Heiner C. |
| Copyright Year | 2004 |
| Abstract | AIMS To evaluate whether stents as compared to balloon angioplasty reduce mortality in patients with non-acute coronary artery disease. METHODS AND RESULTS We identified randomized controlled trials comparing stents to balloon angioplasty for the treatment of non-acute coronary artery disease by searching major medical databases from 1979 to March 2002. Two independent reviewers selected and extracted data from trials that had to report data on death and myocardial infarction. Nineteen trials, with a total of 8004 patients, fulfilled our inclusion criteria. For 1000 patients treated with stents rather than balloon angioplasty, 3 (95% CI 0-6), 5 (95% CI 0-9), and 6 (95% CI -1-12) additional lives were saved at 30 days, 6 and 12 months. At 12 months, for 1000 patients treated with stents rather than balloon angioplasty 46 (95% CI 25-66) additional target vessel revascularizations were avoided, but 25 (95% CI 15-34) additional bleeding complications with need for blood transfusion or surgical intervention occurred. In sensitivity analysis 11 (95% CI 2-20) and 2 (95% CI -4-7) deaths were avoided per 1000 patients treated with stents rather than PTCA in trials that routinely used compared to trials that did not use glycoprotein IIb/IIIa inhibitors. CONCLUSION In non-acute coronary disease stents may reduce overall mortality, but this benefit seems to be limited to stents used in conjunction with glycoprotein IIb/IIIa inhibitors. Stents compared to PTCA reduce target vessel revascularizations, but increase the risk of bleeding complications. |
| Starting Page | 69 |
| Ending Page | 80 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.gastroamrosenberg.ch/upload/prj1/publikationen/eurheartj2004stentvsptca.pdf |
| PubMed reference number | 14683745v1 |
| Volume Number | 25 |
| Issue Number | 1 |
| Journal | European heart journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angioplasty, Balloon Angioplasty, Balloon, Coronary Arteriopathic disease Blood Transfusion Cessation of life Coronary Artery Disease Coronary heart disease Extraction Hemorrhage Myocardial Infarction One Thousand Patients Percutaneous Transluminal Coronary Angioplasty Stent, device |
| Content Type | Text |
| Resource Type | Article |
