Novel effect of vitamin K1 (phylloquinone) and vitamin K2 (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells

Content Provider	Semantic Scholar
Author	Tsang, Chi Kwan Kamei, Yuto
Copyright Year	2002
Abstract	The nerve growth factor (NGF)-potentiating effect of K vitamins on PC12D cells was investigated. Treatment of PC12D cells with vitamin K(1) or K(2) in the presence of NGF significantly enhanced the proportion of neurite-bearing cells and acetylcholinesterase activity compared with NGF treatment alone. The K vitamins-enhanced neurite outgrowth on PC12D cells was completely blocked by a protein kinase A (PKA) inhibitor or mitogen-activated protein kinase (MAPK) kinase inhibitor PD98059, whereas a protein kinase C inhibitor chelerythrine chloride did not significantly inhibit the enhancing effect of the K vitamins. These results suggest that the K vitamins enhance neurite outgrowth via the activation of PKA and MAPK-mediated signaling pathways in PC12D cells.
Starting Page	9
Ending Page	12
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(01)02550-2
PubMed reference number	11911978
Journal	Medline
Volume Number	323
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394001025502
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394001025502?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2801%2902550-2
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article