Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives.

Content Provider	Semantic Scholar
Author	Krug, Eric L. Marr, Jürgen Berens, Randolph L.
Copyright Year	1990
Abstract	The antimalarial compound qinghaosu (artemisinin) was tested in vitro for the ability to inhibit plaque formation by Toxoplasma gondii in fibroblasts. Qinghaosu at 0.4 microgram/ml for 5 days eliminated all plaques and microscopic foci of T. gondii. At 1.3 micrograms/ml for 14 days, qinghaosu completely eliminated T. gondii. Pretreatment of host cells or T. gondii with qinghaosu had no effect on T. gondii growth. There was no apparent toxicity to human fibroblasts in long-term studies. Of the six qinghaosu derivatives tested, dihydroqinghaosu, 1-propyl-ether-qinghaosu, and 1-butyl-ether-qinghaosu were comparable to qinghaosu. Ethyl-ether-qinghaosu (arteether) and sec-butyl-ether-qinghaosu were more effective. Methyl-ether-qinghaosu (artemether) was the most effective, with a potency approximately 10-fold greater than that of qinghaosu.
Starting Page	3281
Ending Page	3302
Page Count	22
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.st-va.ncbi.nlm.nih.gov/pmc/articles/PMC171972/pdf/aac00066-0131.pdf
PubMed reference number	2291661v1
Volume Number	34
Issue Number	10
Journal	Antimicrobial agents and chemotherapy
Language	English
Access Restriction	Open
Subject Keyword	Adverse reaction to drug Antimalarials Dental Plaque Senile Plaques Toxoplasma gondii artemether artemisinine artemotil dihydroartemisinin ethyl ether negative regulation of methyl-branched fatty acid biosynthetic process
Content Type	Text
Resource Type	Article