(NHC)CuI (NHC: N-Heterocyclic Carbene) Complexes as Efficient Catalysts for the Reduction of Carbonyl Compounds.

Content Provider	Semantic Scholar
Author	Kaur, Harneet Zinn, Fabiano Kauer Stevens, Edwin D. Nolan, Steven P.
Copyright Year	2004
Abstract	Organic transformations mediated by organocuprates represent a well-developed area of research.1 Copper complexes have been used in numerous reaction types, including nucleophilic substitutions with alkyl halides, epoxide ring opening, and Michael additions to R,âunsaturated compounds.2 However, in these classical reactions, the copper reagent is used in stoichiometric amounts, making the chemistry less economically and environmentally attractive and rendering product isolation and workups more tedious. The use of catalytic amounts of copper has been demonstrated, but such applications have been restricted to date to couplings of aryl halides3 and reductions of various substrate types.4,5 The use of the thermally stable organocopper(I) hydride cluster [(Ph3P)CuH]6 6 in the selective reduction of enones was introduced by Stryker as an effective metal-mediated reaction.7 Initially, the copper complex was used in stoichiometric amounts in this transformation, but the use of hydrogen sources such as hydrogen gas8 and silanes9 enabled the generation of a Cu-H complex in a catalytic fashion.
File Format	PDF HTM / HTML
DOI	10.1002/chin.200426047
Alternate Webpage(s)	http://www.chem.ccu.edu.tw/~joyce/referance/ericyang/Organometallics/Organometallics%202004,%2023,%201157-1160.pdf
Alternate Webpage(s)	https://doi.org/10.1002/chin.200426047
Volume Number	35
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article