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cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arslan, Paola Hesketh, T. Robin Metcalfe, James C. Pozzan, Tullio |
| Copyright Year | 1984 |
| Abstract | In intact lymphocytes, linoleic acid acts as a typical mitochondrial uncoupler: it substantially decreases the mitochondrial membrane potential and the cellular ATP level, while stimulating oxygen consumption and glycolysis. Under these conditions the inhibition of cellular functions by linoleic acid cannot be attributed to its postulated effects on lipid domains in the plasma membrane. |
| Starting Page | 6524 |
| Ending Page | 6524 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/217/2/419.full.pdf |
| PubMed reference number | 6696740v1 |
| Volume Number | 217 |
| Issue Number | 2 |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenosine Triphosphate Cisplatin Fatty Acids Fatty Liver Glycolysis Linoleic Acid Membrane Potentials Mitochondria Mitochondrial Membranes Plasma membrane Stimulation (motivation) negative regulation of reactive oxygen species biosynthetic process |
| Content Type | Text |
| Resource Type | Article |