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The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Song Crow, John Allen Yang, Xiaoyong Chen, Joseph Borazjani, Ali Mullins, Katie B. Chen, Wei Hua Cooper, R. C. B. McLaughlin, Ronald M. Liao, Jun |
| Copyright Year | 2010 |
| Abstract | Evaluation of structural parameters following a myocardial infarction (MI) is important to assess left ventricular function and remodeling. In this study, we assessed the capability of 3D diffusion tensor magnetic resonance imaging (DT-MRI) to assess tissue degeneration shortly after an MI using a porcine model of infarction. Two days after an induced infarction, hearts were explanted and immediately scanned by a 3T MRI scanner with a diffusion tensor imaging protocol. 3D fiber tracks and clustering models were generated from the diffusion-weighted imaging data. We found in a normal explanted heart that DT-MRI fibers showed a multilayered helical structure, with fiber architecture and fiber density reflecting the integrity of muscle fibers. For infarcted heart explants, we observed either a lack of fibers or disruption of fibers in the infarcted regions. Contours of the disrupted DT-MRI fibers were found to be consistent with the infarcted regions. Both histological and mechanical analysis of the infarcted hearts suggested DT-MRI fiber disruption correlated with altered microstructure and tissue mechanics. The ability of 3D DT-MRI to accurately distinguish viable myocardium from dead myocardium only 2 days post infarct without the use of radioisotopes or ionotropic agents makes it a promising approach to evaluate cardiac damage early post-MI. |
| Starting Page | 3084 |
| Ending Page | 3095 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10439-010-0073-8 |
| PubMed reference number | 20499182 |
| Journal | Medline |
| Volume Number | 38 |
| Alternate Webpage(s) | http://www.cse.msstate.edu/~szhang/papers/Zhang-2010-C3D.pdf |
| Alternate Webpage(s) | http://web.cse.msstate.edu/~szhang/papers/Zhang-2010-C3D.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s10439-010-0073-8 |
| Journal | Annals of Biomedical Engineering |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
