NDLI: Inhibition by transforming growth factor (34-43)-alpha, a TGF-alpha antagonist, of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.

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Inhibition by transforming growth factor (34-43)-alpha, a TGF-alpha antagonist, of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.

Content Provider	Semantic Scholar
Author	Tatsuta, Masaharu Iishi, H. Baba, Miyako Hirasawa, Ryuto Iseki, Kazushige Yano, Hiroyuki Sakai, Noriyoshi Uehara, Hisanori Nakaizumi, Akihiko
Copyright Year	1993
Abstract	The effect of prolonged administration of transforming growth factor (34-43)-alpha, an antagonist of TGF-alpha, on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and on the labelling and apoptotic indices and TGF-alpha immunoreactivity of gastric mucosa and gastric cancers was examined in Wistar rats. The rats received intraperitoneal injections of 10 or 20 microg kg(-1) body weight of TGF(34-43)-alpha every other day after oral treatment with MNNG for 25 weeks. Long-term administration of TGF(34-43)-alpha at both doses significantly reduced the incidence of gastric cancers at the end of the experiment in week 52. However, TGF(34-43)-alpha had no significant effect on the number, histological type or depth of involvement of gastric cancers. Administration of TGF(34-43)-alpha also significantly decreased the bromodeoxyuridine labelling index and TGF-alpha immunoreactivity, and significantly increased the apoptotic index of antral mucosa and gastric cancers. These findings indicate that TGF(34-43)-alpha inhibits gastric carcinogenesis, and that its effects are mediated through decreased cell proliferation and TGF-alpha immunoreactivity and increased apoptosis induction in the gastric cancers.
Starting Page	857
Ending Page	861
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1038/bjc.1998.593
PubMed reference number	9764575
Journal	Medline
Volume Number	78
Journal	British Journal of Cancer
Alternate Webpage(s)	http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=7F601454A72A811E9A94A8FC009FB55C?doi=10.1.1.279.7666&rep=rep1&type=pdf
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/c5/7d/brjcancer00011-0021.PMC2063135.pdf
Alternate Webpage(s)	https://doi.org/10.1038/bjc.1998.593
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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