The effect of scorpion venom tityustoxin on the uptake of calcium in synaptosomes

Content Provider	Semantic Scholar
Author	Henriques, M. Celeste Gomez, Marcus Vinicius
Copyright Year	1981
Abstract	The effect of tityustoxin on calcium uptake in synaptosomes incubated in hypotonic medium low sodium and physiological medium high sodium was studied. In the hypotonic medium, calcium uptake was ATP and temperature dependent and TsTX inhibits this uptake. The inhibition of calcium uptake was not due to an osmotic effect since it was also observed in conditions of physiological cell osmolarity. In the physiological medium high sodium, tityustoxin stimulated calcium uptake in synaptosomes. The effect was inhibited by tetrodotoxin and cocaine. The stimulating effect of tityustoxin was specific for sodium concentration in the medium and neither choline nor sucrose could substitute sodium in its activation of the stimulation of calcium uptake in synaptosomes by tityustoxin.
Starting Page	255
Ending Page	259
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/0361-9230(81)90016-2
PubMed reference number	7272801
Journal	Medline
Volume Number	7
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0361923081900162
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0361923081900162?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0361-9230%2881%2990016-2
Journal	Brain Research Bulletin
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article