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Nitrergic relaxation of gastrointestinal smooth muscle: role of interstitial cells of Cajal and smooth muscle cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lies, Barbara Groneberg, Dieter Saur, Dieter König, Peter Friebe, Andreas |
| Copyright Year | 2011 |
| Abstract | Background The signaling molecule nitric oxide (NO) is known to activate the enzyme NO-sensitive guanylyl cyclase (NOGC). By generation of the intracellular second messenger cGMP NO-GC regulates many physiological processes. In the gastrointestinal (GI) tract nitrergic neurons are part of the enteric nervous system which regulates GI motility. In addition, interstitial cells of Cajal (ICC) are thought to be involved in nitrergic relaxation. In this study, we intended to clarify the role of NO-GC regarding GI motility in mice by using cellspecific knockout strains. |
| Starting Page | P44 |
| Ending Page | P44 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://bmcpharma.biomedcentral.com/track/pdf/10.1186/1471-2210-11-S1-P44 |
| PubMed reference number | 3363239 |
| Volume Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action CNS disorder Cell signaling Cyclic GMP Enteric Nervous System Guanylate Cyclase Interstitial Cells of Cajal Interstitial webpage Knockout Lagrangian relaxation Linear programming relaxation Muscle Cells Myalgia Myocytes, Smooth Muscle Nitrergic Neurons Nitric Oxide Physiological Processes Second Messenger Systems Smooth muscle (tissue) Tract (literature) soluble guanylyl cyclase |
| Content Type | Text |
| Resource Type | Article |
