NDLI: Human Embryonic Stem Cell-Derived Neurons as a Tool for Studying Neuroprotection and Neurodegeneration

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Human Embryonic Stem Cell-Derived Neurons as a Tool for Studying Neuroprotection and Neurodegeneration

Content Provider	Semantic Scholar
Author	Hardingham, Giles E. Patani, Rickie Baxter, Paul Wyllie, David J. A. Chandran, Siddharthan
Copyright Year	2010
Abstract	The capacity to generate myriad differentiated cell types, including neurons, from human embryonic stem (hES) cell lines offers great potential for developing cell-based therapies and also for increasing our understanding of human developmental mechanisms. In addition, the emerging development of this technology as an experimental tool represents a potential opportunity for neuroscientists interested in mechanisms of neuroprotection and neurodegeneration. Potentially unlimited generation of well-defined functional neurons from hES and patient-specific induced pluripotent cells offers new systems to study disease mechanisms, signalling pathways and receptor pharmacology within a human cellular environment. Such systems may help in overcoming interspecies differences. Far from replacing rodent in vivo and primary culture systems, hES and induced disease-specific pluripotent stem cell-derived neurons offer a complementary resource to overcome issues of interspecies differences, accelerate drug discovery, study of disease mechanism and provide basic insight into human neuronal physiology.
Starting Page	97
Ending Page	102
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1007/s12035-010-8136-2
PubMed reference number	20431962
Journal	Medline
Volume Number	42
Alternate Webpage(s)	https://www.research.ed.ac.uk/portal/files/8257187/Human_embryonic_stem_cell_derived_neurons_as_a_tool_for_studying_neuroprotection_and_neurodegeneration..pdf
Alternate Webpage(s)	http://www.research.ed.ac.uk/portal/files/8257187/Human_embryonic_stem_cell_derived_neurons_as_a_tool_for_studying_neuroprotection_and_neurodegeneration..pdf
Alternate Webpage(s)	https://doi.org/10.1007/s12035-010-8136-2
Journal	Molecular Neurobiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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