NDLI: Effet de la prise orale de glutamine sur la fonction et la masse musculaire dans la dystrophie de Duchenne de Boulogne

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Effet de la prise orale de glutamine sur la fonction et la masse musculaire dans la dystrophie de Duchenne de Boulogne

Content Provider	Semantic Scholar
Author	Mok, Elise
Copyright Year	2008
Abstract	Background:Glutaminehas been shown to acutely decreasewhole- body protein degradation in Duchenne muscular dystrophy (DMD). Objective: To improve nutritional support in DMD, we tested whether oral supplementation with glutamine for 10 d decreased whole-body protein degradation significantly more than did an iso- nitrogenous amino acid control mixture. Design: Twenty-six boys with DMDwere included in this random- ized, double-blind parallel study; they received an oral supplement of either glutamine (0.5 g · kg 1 · d ) or an isonitrogenous, non- specific amino acidmixture (0.8 g · kg 1 · d ) for 10 d. The subjects in each group were not clinically different at entry. Leucine and glutaminemetabolismswere estimated in the postabsorptive state by using a primed continuous intravenous infusion of [1-C]leucine and [2-N]glutamine before and 10 d after supplementation. Results: A significant effect of time was observed on estimates of whole-body protein degradation. A significant (P 0.05) decrease in the rate of leucine appearance (an index of whole-body protein degradation) was observed after both glutamine and isonitrogenous amino acid supplementation [x SEM: 136 9 to 124 6 mol · kg fat-free mass (FFM) 1 · h 1 for glutamine and 136 6 to 131 8 mol · kg FFM 1 · h 1 for amino acids]. A significant (P 0.05) decrease in endogenous glutamine due to protein breakdown was alsoobserved (91 6 to83 4 mol · kgFFM 1 · h 1 for glutamine and 91 4 to 88 5 mol · kg FFM 1 · h 1 for amino acids). The decrease in the estimates of whole-body protein degradation did not differ significantly between the 2 supplemental groups. Conclusion:Oral glutamine or amino acid supplementation over 10 d equally inhibits whole-body protein degradation in DMD. Am J Clin Nutr 2006;83:823–8.
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Alternate Webpage(s)	http://nuxeo.edel.univ-poitiers.fr/nuxeo/site/esupversions/51b1213f-5115-48bc-81a7-6dab6caf03a0
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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