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Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hou, Huiying Zhao, Yange Yu, Wenqing Dong, Hualei Xue, Xiaotong Ding, Jian Xing, Weijia Wang, Wei |
| Copyright Year | 2018 |
| Abstract | Background Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI). Results Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980, P < 0.05). Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 (95% CI = 1.093-1.274, P < 0.05) for mild OSA, 1.316 (95% CI = 1.197-1.433, P < 0.05) for moderate OSA and 1.561 (95% CI = 1.287-1.835, P < 0.05) for severe OSA. Conclusions Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients. |
| Starting Page | 250 |
| Ending Page | 255 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jogh.org/documents/issue201801/jogh-08-010405.pdf |
| Alternate Webpage(s) | https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=5245&context=ecuworkspost2013 |
| Alternate Webpage(s) | http://www.jogh.org/documents/issue201801/jogh-08-010405-s001.pdf |
| PubMed reference number | 5825975 |
| Alternate Webpage(s) | https://doi.org/10.7189/jogh.08.010405 |
| DOI | 10.7189/jogh.08.010405 |
| Journal | Journal of global health |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Confidence Intervals Essential Hypertension Hypertensive disease Mandibular right second molar tooth Mental association Odds Ratio Patients Pooled Sample Scientific Publication Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders |
| Content Type | Text |
| Resource Type | Article |
