Loading...
Please wait, while we are loading the content...
Similar Documents
Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Johnston, Donna L. Alonzo, Todd A. Gerbing, Robert B. Hirsch, Betsy A. Heerema, Nyla A. Ravindranath, Yaddanapudi Woods, William G. Lange, Beverly J. Gamis, Alan S. Raimondi, Susana C. |
| Copyright Year | 2013 |
| Abstract | BACKGROUND Abnormalities of chromosome 5q (-5/5q-) are associated with poor prognosis in adults with acute myeloid leukemia (AML). However, there are no large studies on outcomes of children with -5/5q- AML. To determine the disease correlates of this group, we retrospectively analyzed cytogenetic data from five studies of childhood AML. PROCEDURE Data from patients whose cytogenetic clones included -5/5q-, with the exception of those with acute promyelocytic leukemia or Down syndrome, were included. RESULTS Of the 2,240 patients with cytogenetic data available, 26 (1.2%) had -5 or 5q-. A significant number of these patients were age 11-21 (61.5%, P = 0.031) and had M0 morphology compared with patients without -5/5q- (24.0% vs. 2.8%, P < 0.001). Twenty-two of the 26 patients had a complete remission (CR) response to induction chemotherapy. The 5-year overall survival (OS) from the time of diagnosis for the -5/5q- patients was significantly lower than for patients without -5/5q- (27 ± 17% vs. 50 ± 2%, P = 0.027). Similarly, from induction CR, patients with -5/5q- had significantly worse disease free survival, OS and relapse risk than those without this abnormality (27 ± 19% vs. 46 ± 2%, P = 0.035, 32 ± 20% vs. 57 ± 2%, P = 0.025, 68 ± 21% vs. 45 ± 2%, P = 0.01, respectively). CONCLUSIONS Pediatric patients with AML and -5/5q- had a very poor outcome. These findings support the need for new or novel therapies for these patients. |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/pbc.24573 |
| PubMed reference number | 24039149 |
| Journal | Medline |
| Volume Number | 60 |
| Issue Number | 12 |
| Alternate Webpage(s) | http://www.slaop.org/pdf/24235.Leucemia%20Outcome%20of%20pediatric%20patients%20with%20acute%20myeloid%20leukemia%20AML%20and%20abnormalities%20from%20five%20pediatric%20AML%20treatment%20protocols%20A%20report%20from%20the%20Childrens%20Oncology%20Group.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/pbc.24573 |
| Journal | Pediatric blood & cancer |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Report |
