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Methylphosphonic Dichloride as Reagent for the Determination of the Enantiomeric Excess of Chiral Thiols. Scope and Limitations
| Content Provider | Semantic Scholar |
|---|---|
| Author | Strijtveen, Bert Feringa, Bernard Kellogg, Richard M. |
| Copyright Year | 1987 |
| Abstract | Abstract Methylphosphonic dichloride, CH3P(=O)Cl2 , reacts cleanly and quantitatively with thiols to form dialkylthiophosphonates, CH3P(=O) (SR)2. From the ratio of the integrations of the 31P absorptions in the NMR spectra, the enantiomeric excesses of the thiols can be obtained for the cases that R is chiral. The effect of structural change in the phosphorus derivatizing reagent on the separation of peaks in the 31P NMR spectra has been examined, especially the effects of variations in electronegativity and/or steric bulk. The effect of the temperature on the peak separation was also studied. |
| Starting Page | 123 |
| Ending Page | 130 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0040-4020(01)89938-5 |
| Volume Number | 43 |
| Alternate Webpage(s) | https://www.rug.nl/research/portal/files/3383917/1987TetrahedronStrijtveen.PDF |
| Alternate Webpage(s) | https://doi.org/10.1016/S0040-4020%2801%2989938-5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
