NDLI: RANKL Reduces Body Weight and Food Intake via the Modulation of Hypothalamic NPY/CART Expression

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RANKL Reduces Body Weight and Food Intake via the Modulation of Hypothalamic NPY/CART Expression

Content Provider	Semantic Scholar
Author	Zhu, Ping Zhang, Zhihui Huang, Xufeng Liang, Shiyu Khandekar, Neeta Song, Zhiyuan
Copyright Year	2018
Abstract	The receptor activator of nuclear factor-κB ligand (RANKL) modulates energy metabolism. However, how RANKL regulates energy homeostasis is still not clear. This study aims to investigate the central mechanisms by which central administration of RANKL inhibits food intake and causes weight loss in mice. We carried out a systematic and in-depth analysis of the neuronal pathways by which RANKL mediates catabolic effects. After intracerebroventricle (i.c.v.) injection of RANKL, the expression of neuropeptide Y (NPY) mRNA in the Arc was significantly decreased, while the CART mRNA expression dramatically increased in the Arc and DMH. However, the agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) mRNA had no significant changes compared with control groups. Together, the results suggest that central administration of RANKL reduces food intake and causes weight loss via modulating the hypothalamic NPY/CART pathways.
Starting Page	969
Ending Page	977
Page Count	9
File Format	PDF HTM / HTML
DOI	10.7150/ijms.24373
PubMed reference number	30013437
Journal	Medline
Volume Number	15
Alternate Webpage(s)	http://www.medsci.org/v15p0969.pdf
Alternate Webpage(s)	https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2286&context=ihmri
Alternate Webpage(s)	https://doi.org/10.7150/ijms.24373
Journal	International journal of medical sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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