NDLI: N-Methyl-d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo

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N-Methyl-d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo

Content Provider	Semantic Scholar
Author	Whitton, Peter S. Richards, David Adams Biggs, Christopher S. Fowler, Leslie J.
Copyright Year	1994
Abstract	The effects of infusing N-methyl-D-aspartate (NMDA) and the specific NMDA receptor antagonist D-2-amino-5-phosphonopropionic acid (D-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intracerebral microdialysis. In striatum, NMDA (1-100 microM) caused a concentration-dependent increase in 5-HT. D-AP5 (10 microM) infusion caused increased extracellular 5-HT. When the two drugs were co-infused, no effect on extracellular 5-HT was seen. D-AP5 alone was found to cause a delayed but sustained increase in dialysate 5-HIAA. In hippocampus, NMDA infusion caused a dose-dependent decrease in extracellular 5-HT while D-AP5 produced a transitory increase in 5-HT level. NMDA caused a decrease in dialysate 5-HIAA. In striatum, the effect of 10 microM NMDA infusion was abolished by co-infusion with tetrodotoxin (TTX; 1 microM). In hippocampus, 1 microM TTX caused a slight but non-significant augmentation of the effect of 10 microM NMDA alone. These data indicate that NMDA receptors mediate control over 5-HT release and metabolism in different brain regions and may in part explain the behavioural effects of non-competitive NMDA receptor antagonists.
Starting Page	215
Ending Page	218
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(94)90395-6
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394094903956
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394094903956?dgcid=api_sd_search-api-endpoint
PubMed reference number	7519338
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2894%2990395-6
Journal	Medline
Volume Number	169
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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