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Universidade Federal De Pernambuco Centro De Ciências Da Saúde Departamento De Ciências Farmacêuticas Programa De Pós-graduação Em Ciências Farmacêuticas
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rocha, Cristiane Santos Da |
| Copyright Year | 2003 |
| Abstract | The species Hyptis martiusii Benth. belongs to the family Lamiaceae and grows in abundance in northeastern Brazil, where is popularly known as cidreira-do-mato or cidreira-brava. Its leaves and roots are traditionally used in folk medicine in the treatment of intestinal and stomachic diseases. Characterized by providing an essential oil rich in terpene compounds, a class of compounds that has demonstrated potential antiulcer activity. Based on the interesting phytochemical profile of this species, this study aimed to characterize the chemical constituents and evaluate the possible antiulcerogenic action of essential oil from leaves of Hyptis martiusii (EOHM) in models of experimental ulcers in vivo in rodents. Were used acute models of gastric ulcer induced by indomethacin, absolute ethanol and acidified ethanol. The volume, pH and total acidity of gastric juice were determined by the pyloric ligature method and gastrointestinal motility using the method of gastric emptying and intestinal transit. Chemical analysis of EOHM identified 24 constituents representing 92% and indicated the existence of mono and sesquiterpenes. It was observed that EOHM (100, 200 and 400 mg/kg) administered orally showed significant gastroprotective effect dosedependent in the models of gastric lesions induced by absolute ethanol (70%), ethanol acidified and indomethacin, indicating that the EOHM exerts a cytoprotective and which probably acts by increasing the protective factors of gastric mucosa as mucus and/or bicarbonate. When administered intraduodenally, increased the pH and decreased the gastric acidity only with the highest doses, however not changed the volume of gastric juice, suggesting that the decrease in gastric acidity involves an anti-secretory mechanism, via receptors and/or mediators of parietal cell. The EOHM reduced the rate of gastric emptying with only the highest doses, but did not show influence on intestinal transit in neither of three doses. Thus, it is concluded that the essential oil of Hyptis martiusii has gastroprotective effect by a mechanism of action not yet unclear and probably this effect observed may be related to the presence of the terpenes. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/2957/1/arquivo1123_1.pdf |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/10258/1/Tese%20ROLIM%20LA%20PPGCF%20UFPE%202012.pdf |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/17190/1/Disserta%C3%A7%C3%A3o%20Ellison%20Neves%20de%20Lima.pdf |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/10639/1/Disserta%C3%A7%C3%A3o%20Anne%20Cec%C3%ADlia%20da%20Cruz.pdf |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/10761/1/Disserta%C3%A7%C3%A3o%20Vanessa%20da%20Silva%20Luna.pdf |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/3287/1/arquivo2745_1.pdf |
| Alternate Webpage(s) | https://repositorio.ufpe.br/bitstream/123456789/3245/1/arquivo2146_1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
