NDLI: Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.

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Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.

Content Provider	Semantic Scholar
Author	Andrews, Nicolas P. Pack, Christopher D. Lukacher, Aron E.
Copyright Year	2008
Abstract	The CD8 coreceptor is important for positive selection of major histocompatibility complex I (MHC-I)-restricted thymocytes and in the generation of pathogen-specific T cells. However, the requirement for CD8 in these processes may not be essential. We previously showed that mice lacking beta(2)-microglobulin are highly susceptible to tumors induced by mouse polyoma virus (PyV), but CD8-deficient mice are resistant to these tumors. In this study, we show that CD8-deficient mice also control persistent PyV infection as efficiently as wild-type mice and generate a substantial virus-specific, MHC-I-restricted, T-cell response. Infection with vesicular stomatitis virus (VSV), which is acutely cleared, also recruited antigen-specific, MHC-I-restricted T cells in CD8-deficient mice. Yet, unlike in VSV infection, the antiviral MHC-I-restricted T-cell response to PyV has a prolonged expansion phase, indicating a requirement for persistent infection in driving T-cell inflation in CD8-deficient mice. Finally, we show that the PyV-specific, MHC-I-restricted T cells in CD8-deficient mice, while maintained long term at near-wild-type levels, are short lived in vivo and have extremely narrow T-cell receptor repertoires. These findings provide a possible explanation for the resistance of CD8-deficient mice to PyV-induced tumors and have implications for the maintenance of virus-specific MHC-I-restricted T cells during persistent infection.
File Format	PDF HTM / HTML
DOI	10.1128/JVI.02698-07
PubMed reference number	18337581
Journal	Medline
Volume Number	82
Issue Number	10
Alternate Webpage(s)	http://jvi.asm.org/content/82/10/4697.full.pdf
Alternate Webpage(s)	https://doi.org/10.1128/JVI.02698-07
Journal	Journal of virology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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