NDLI: Restrictive vs . liberal transfusion for cancer patients : a meta-analysis of randomized controlled trials

Content Provider	Semantic Scholar
Author	Luo, Binrui Yang, Dong-Mei Cheng, Fu Huang, Yuan-Shuai
Copyright Year	2018
Abstract	Objective: We attempted to find a more suitable blood transfusion strategy for cancer patients by comparing restrictive transfusion with liberal transfusion treatment results. Methods: In order to find all randomized controlled trials (RCT) which are relevant to comparison on restrictive transfusion with liberal transfusion treatment results, we have searched PubMed, EMBASE and Cochrane library database. Results: Five papers were finally included in our meta-analysis. Restrictive transfusion significantly decreased blood utilization (standard mean difference=-0.33, 95% CI=-0.5-0.17, P<0.0001). The incidence of 60-day mortality was significantly lower in cancer patients receiving liberal transfusion than those receiving restrictive transfusion (OR=1.58, 95% CI=1.08-2.33, P=0.02). There was no significant difference in length of hospitalization, ICU length of stay, bleeding events, ICU readmission and response after chemotherapy (response rate) between the two groups. Conclusion: According to our current study, liberal transfusion strategy was recommended for cancer patients. In the future, well-designed and larger sample sizes of RCTs are still needed.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijcem.com/files/ijcem0064978.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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