NDLI: The stereospecificity of sequential nicotinamide-adenine dinucleotide-dependent oxidoreductases in relation to the evolution of metabolic sequences.

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The stereospecificity of sequential nicotinamide-adenine dinucleotide-dependent oxidoreductases in relation to the evolution of metabolic sequences.

Content Provider	Semantic Scholar
Author	Nascimento, K. H. Do Davies, David D.
Copyright Year	1975
Abstract	The generalization that 'when a metabolic sequence involves consecutive nicotinamide-adenine dinucleotide-dependent reactions, the dehydrogenases have the same stereospecificity' was tested and confirmed for three metabolic sequences. (1) NAD+-xylitol (D-xylulose) dehydrogenase and NADP+-xylitol (L-xylulose) dehydrogenase are both B-specific. (2) D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase are both B-specific. (3) meso Tartrate dehydrogenase and oxaloglycollate reductive decarboxylase are both A-specific. Other dehydrogenases associated with the metabolism of meso-tartrate in Pseudomonas putida, such as hydroxypyruvate reductase and tartronate semialdehyde reductase, were also shown to be A-specific. Malate dehydrogenase from Pseudomonas putida was A-specific, and the proposition is discussed that the common A-stereospecificity among the dehydrogenases involved in meso-tartrate metabolism reflects their origin from malate dehydrogenase.
Starting Page	259
Ending Page	264
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemj.org/content/ppbiochemj/149/3/553.full.pdf
PubMed reference number	1200995v1
Volume Number	149
Issue Number	3
Journal	The Biochemical journal
Language	English
Access Restriction	Open
Subject Keyword	Aromatic-L-Amino-Acid Decarboxylases Carboxy-Lyases Dinucleoside Phosphates Generalization (Psychology) Hydroxypyruvate reductase Mannitol Metabolic Process, Cellular Niacin Nicotinamide adenine dinucleotide (NAD) Oxidoreductase Pseudomonas putida Tartrates Xylulose malate sorbitol biosynthetic process tartrate metabolic process
Content Type	Text
Resource Type	Article

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