NDLI: Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis

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Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis

Content Provider	Semantic Scholar
Author	Ma, Yue Ratnasabapathy, Risheka Izzi-Engbeaya, Chioma Nguyen-Tu, Marie-Sophie Richardson, Emma Hussain, Sufyan Backer, Ivan De Holton, Christopher James. Norton, Mariana Carrat, Gaelle R. J. Schwappach, Blanche Rutter, Guy A. Dhillo, Waljit S. Gardiner, James
Copyright Year	2018
Abstract	AIMS To investigate the role of arcuate glucokinase (GK) in the regulation of glucose homeostasis. MATERIALS AND METHODS A recombinant adeno-associated virus expressing either GK or an antisense GK construct was used to alter GK activity specifically in the hypothalamic arcuate nucleus (arc). GK activity in this nucleus was also increased by stereotactic injection of the GK activator, compound A. The effect of altered arc GK activity on glucose homeostasis was subsequently investigated using glucose and insulin tolerance tests. RESULTS Increased GK activity specifically within the arc increased insulin secretion and improved glucose tolerance in rats during oral glucose tolerance tests. Decreased GK activity in this nucleus reduced insulin secretion and increased glucose levels during the same tests. Insulin sensitivity was not affected in either case. The effect of arc GK was maintained in a model of type 2 diabetes. CONCLUSIONS These results demonstrate a role for arc GK in systemic glucose homeostasis.
Starting Page	2246
Ending Page	2254
Page Count	9
File Format	PDF HTM / HTML
PubMed reference number	29748994v1
Alternate Webpage(s)	https://doi.org/10.1111/dom.13359
DOI	10.1111/dom.13359
Journal	Diabetes, obesity & metabolism
Volume Number	20
Language	English
Access Restriction	Open
Subject Keyword	Cell Nucleus Dependovirus Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent GCK gene Glucose Metabolism Disorders Glucose tolerance test Hyperinsulinism Recombinants Satellite Viruses Structure of nucleus infundibularis hypothalami antisense therapy insulin secretion
Content Type	Text
Resource Type	Article

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