NDLI: Estudo da toxicidade genética relacionada ao tratamento combinado de doxorrubicina e cardioxane em células somáticas de Drosophila melanogaster

Content Provider	Semantic Scholar
Author	Possenti, Samantha Filho, Ronaldo Gayescki Campana Lehmann, Maurício
Copyright Year	2005
Abstract	O presente trabalho procurou avaliar a toxicidade genetica da combinacao dos compostos dexrazoxano(DEX) e doxorrubicina (DOX) atraves do Teste SMART em celulas somaticas de Drosophilamelanogaster. Os dados obtidos indicaram que: (i) a DOX nas concentracoes de 0,75 e 1,5 mM naofoi capaz de induzir aumentos significativos na frequencia de manchas quando comparada ao controlenegativo (CN); (ii) o DEX nas tres concentracoes utilizadas (5; 10 e 20 mM), aumentou a frequenciade lesoes geneticas em relacao ao CN; (iii) a combinacao destes farmacos induziu o mesmo numero delesoes que o tratamento isolado com DEX, indicando ausencia de aditividade, sinergismo ou antagonismo;(iv) a frequencia de lesoes relacionadas a recombinacao mitotica foi menor nos tratamentos combinadosque nos tratamentos isolados.Palavras-chave: ICRF-187, genotoxicidade, Drosophila melanogaster, recombinacao, topoisomerase.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.periodicos.ulbra.br/index.php/ic/article/download/1858/1327
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in