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Ingestive behavior in adult rats with dorsomedial hypothalamic lesions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dalton, Lawrence D. Carpenter, Richard G. Grossman, Sebastian P. |
| Copyright Year | 1981 |
| Abstract | Abstract Large lesions in the dorsomedial hypothalamus (DMH) resulted in transient hypophagia that produced a significant weight loss. Energy intake per g of body weight returned to normal levels within 2 weeks after surgery but the body weight loss incurred during the immediate postoperative period was not compensated in 3 months of observation. The experimental animals responded poorly, if at all, to 2-deoxy-D-glucose induced cellular glucoprivation but ate normally after 2 doses of insulin and compensated appropriately for 24 hours of food deprivation. Rats with DMH lesions also displayed persisting hypodipsia (even when the animals' reduced body weights were taken into account) but responded normally, or nearly so, to water deprivation (with and without food), cellular dehydration, or extracellular hypovolemia. (Rats with DMH lesions drank slightly less than controls on most of these tests even when their chronically lowered body weights were taken into account but the impairment was small and, in most instances, not statistically reliable.) |
| Starting Page | 117 |
| Ending Page | 123 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0031-9384(81)90086-X |
| PubMed reference number | 7015378 |
| Journal | Medline |
| Volume Number | 26 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/003193848190086X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/003193848190086X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0031-9384%2881%2990086-X |
| Journal | Physiology & Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
