NDLI: Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation.

Please wait, while we are loading the content...

Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation.

Content Provider	Semantic Scholar
Author	Dewing, Phoebe Shi, Tao Zhong Horvath, Steve Vilain, Eric
Copyright Year	2003
Abstract	The classic view of brain sexual differentiation and behavior is that gonadal steroid hormones act directly to promote sex differences in neural and behavioral development. In particular, the actions of testosterone and its metabolites induce a masculine pattern of brain development, while inhibiting feminine neural and behavioral patterns of differentiation. However, recent evidence indicates that gonadal hormones may not solely be responsible for sex differences in brain development and behavior between males and females. Here we examine an alternative hypothesis that genes, by directly inducing sexually dimorphic patterns of neural development, can influence the sexual differences between male and female brains. Using microarrays and RT-PCR, we have detected over 50 candidate genes for differential sex expression, and confirmed at least seven murine genes which show differential expression between the developing brains of male and female mice at stage 10.5 days post coitum (dpc), before any gonadal hormone influence. The identification of genes differentially expressed between male and female brains prior to gonadal formation suggests that genetic factors may have roles in influencing brain sexual differentiation.
Starting Page	82
Ending Page	90
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://sindromebenjamin.tripod.com/sitebuildercontent/sitebuilderfiles/mousestudy.pdf
Alternate Webpage(s)	http://blogttn.info/dspace/rh/download_bumes.pdf
Alternate Webpage(s)	http://www.shb-info.org/sitebuildercontent/sitebuilderfiles/4_vilain_et_al.pdf
PubMed reference number	14559357v1
Volume Number	118
Issue Number	1-2
Journal	Brain research. Molecular brain research
Language	English
Access Restriction	Open
Subject Keyword	Candidate Disease Gene Cell Differentiation process Gene Expression Gonadal Dysgenesis, 46,XY Gonadal Hormones Gonadal Steroid Hormones Gonadal structure Inhibition Metabolite Neurogenesis Sex Characteristics Sex Differentiation Steroid hormone Steroids Testosterone brain development feminine masculine
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in