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Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huszar, Dennis Varban, M. L. Rinninger, Franz Feeley, Ruth M. Arai, T. Fairchild-Huntress, Victoria Donovan, Michael J. Tall, Alan R. |
| Copyright Year | 2000 |
| Abstract | Scavenger receptor BI (SR-BI) is a multiligand cell-surface receptor that plays a central role in high density lipoprotein homeostasis in rodents. To investigate a role for SR-BI in atherosclerosis, mice with attenuated SR-BI expression were crossed with low density lipoprotein (LDL) receptor-deficient mice. Compound-homozygous mutants showed increased plasma cholesterol, surprisingly due primarily to increased LDL cholesterol and apolipoprotein B levels. LDL turnover studies showed that this resulted from increased LDL cholesterol production rather than decreased LDL catabolism. Atherosclerotic lesion size was significantly increased in male compound-mutant mice relative to LDL receptor-deficient controls (93 427+/-16 079 versus 34 448+/-5 331 microm(2), respectively; P=0.003). The proatherogenic effect of attenuated SR-BI expression may in part be due to increased LDL cholesterol levels. These findings suggest that upregulation of the receptor could have therapeutic potential for the treatment of atherosclerosis. |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/01.ATV.20.4.1068 |
| PubMed reference number | 10764675 |
| Journal | Medline |
| Volume Number | 20 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/20/4/1068.full.pdf |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/20/4/1068.full.pdf |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/20/4/1068.full.pdf?download=true |
| Alternate Webpage(s) | https://doi.org/10.1161/01.ATV.20.4.1068 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
