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Chitosan oligosaccharides inhibit TNF-α-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Hongtao Li, Wen-Ming Huang, Pei Wen Chen, Wen-Juan Liu, Qishun Bai, Xuefang Yu, Chao Du, Yuguang |
| Copyright Year | 2010 |
| Abstract | This study aimed to investigate the inhibitive effects of chitosan oligosaccharides (COS) on tumor necrosis factor (TNF)-alpha-induced over-expression of vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs). We found that COS effectively inhibited TNF-alpha-induced expression of VCAM-1 and ICAM-1 at the level of transcription and translation. Signal transduction studies suggested that COS blocked TNF-alpha-induced activation of NF-kappa B, degradation of I kappa B alpha, and phosphorylation of p38 MAPK and ERK1/2. A further investigation showed that the NF-kappa B activation can be partly suppressed by p38 MAPK inhibitor (58203580) and ERK1/2 inhibitor (PD98059), which also ameliorated the mRNA expression of VCAM-1 and ICAM-1 in TNF-alpha-induced HUVECs. Additionally, COS decreased U937 monocyte adhesion to HUVECs induced by TNF-alpha. Our findings suggest that COS inhibit VCAM-1 and ICAM-1 production in activated HUVECs at least partly through the blockade of p38 and ERK1/2 signaling pathways. (C) 2010 Elsevier Ltd. All rights reserved. |
| Starting Page | 49 |
| Ending Page | 56 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.carbpol.2010.01.054 |
| Volume Number | 81 |
| Alternate Webpage(s) | http://www.beyotime.com/reference/an365-4-a0208-10-s1006-ref3.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.carbpol.2010.01.054 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
