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Heteronuclear Ir(III)-Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jana, Atanu Crowston, Bethany J. Shewring, Jonathan R. Mckenzie, Luke K. Bryant, Helen E. Botchway, Stanley W. Ward, Andrew D. Amoroso, Angelo J. Baggaley, Elizabeth Ward, Michael D. |
| Copyright Year | 2016 |
| Abstract | Luminescent, mixed metal d-f complexes have the potential to be used for dual (magnetic resonance imaging (MRI) and luminescence) in vivo imaging. Here, we present dinuclear and trinuclear d-f complexes, comprising a rigid framework linking a luminescent Ir center to one (Ir·Ln) or two (Ir·Ln2) lanthanide metal centers (where Ln = Eu(III) and Gd(III), respectively). A range of physical, spectroscopic, and imaging-based properties including relaxivity arising from the Gd(III) units and the occurrence of Ir(III) → Eu(III) photoinduced energy-transfer are presented. The rigidity imposed by the ligand facilitates high relaxivities for the Gd(III) complexes, while the luminescence from the Ir(III) and Eu(III) centers provide luminescence imaging capabilities. Dinuclear (Ir·Ln) complexes performed best in cellular studies, exhibiting good solubility in aqueous solutions, low toxicity after 4 and 18 h, respectively, and punctate lysosomal staining. We also demonstrate the first example of oxygen sensing in fixed cells using the dyad Ir·Gd, via two-photon phosphorescence lifetime imaging (PLIM). |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/acs.inorgchem.6b00702 |
| PubMed reference number | 27219675 |
| Journal | Medline |
| Volume Number | 55 |
| Issue Number | 11 |
| Alternate Webpage(s) | http://orca-mwe.cf.ac.uk/91260/7/Main_Text_REV_Inorg_Chem_05MAY16b%20(1).pdf |
| Alternate Webpage(s) | http://orca.cf.ac.uk/91260/7/Main_Text_REV_Inorg_Chem_05MAY16b%20(1).pdf |
| Alternate Webpage(s) | http://orca-mwe.cf.ac.uk/91260/1/acs.inorgchem.6b00702.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/acs.inorgchem.6b00702 |
| Journal | Inorganic chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
