Loading...
Please wait, while we are loading the content...
Antigen-induced airway inflammation in the Brown Norway rat results in airway smooth muscle hyperplasia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xu, Kuan Feng Vlahos, Ross Messina, Aurora Bamford, Terry Bertram, John F. Stewart, Alastair G. |
| Copyright Year | 2002 |
| Abstract | Asthma is characterized by chronic airways inflammation, airway wall remodeling, and airway hyperresponsiveness (AHR). An increase in airway smooth muscle has been proposed to explain a major part of AHR in asthma. We have used unbiased stereological methods to determine whether airway smooth muscle hyperplasia and AHR occurred in sensitized, antigen-challenged Brown Norway (BN) rats. Ovalbumin (OA)-sensitized BN rats chronically exposed to OA aerosol displayed airway inflammation and a modest level of AHR to intravenously administered ACh 24 h after the last antigen challenge. However, these animals did not show an increase in smooth muscle cell (SMC) number in the left main bronchus, suggesting that short-lived inflammatory mechanisms caused the acute AHR. In contrast, 7 days after the last aerosol challenge, there was a modest increase in SMC number, but no AHR to ACh. Addition of FCS to the chronic OA challenge protocol had no effect on the degree of inflammation but resulted in a marked increase in both SMC number and a persistent (7-day) AHR. These results raise the possibility that increases in airway SMC number rather than, or in addition to, chronic inflammation contribute to the persistent AHR detected in this model. |
| Starting Page | 66 |
| Ending Page | 73 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jap.physiology.org/content/jap/93/5/1833.full.pdf |
| PubMed reference number | 12381772v1 |
| Volume Number | 93 |
| Issue Number | 5 |
| Journal | Journal of applied physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Aerosol Dose Form Airway Obstruction Airway structure Bronchi Chronic Obstructive Airway Disease Dermatitis Fetal Bovine Serum Left main bronchus structure Muscle Cells Myocytes, Smooth Muscle Ovalbumin Rats, Inbred BN Respiratory Hypersensitivity Sacroiliitis Smooth muscle (tissue) smooth muscle hyperplasia |
| Content Type | Text |
| Resource Type | Article |
