NDLI: Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties.

Content Provider	Semantic Scholar
Author	Liu, Pengxing Lu, Yanhui Gao, Xiangqian Zhang-Negrerie, Daisy Shi, Ying Wang, Yiqiang Wang, Songqing Gao, Qingzhi
Copyright Year	2013
Abstract	Glucose-conjugated malonato-platinum(II) complexes are designed and synthesized to target tumor-specific active transporters, namely, glucose transporters (GLUTs); the complexes exhibit much higher aqueous solubility by 150 times, improved potency in cytotoxicities by 10 times, and increased therapeutic index by over 30 fold compared to the newest generation of clinical drugs oxaliplatin.
File Format	PDF HTM / HTML
DOI	10.1039/c3cc38589b
PubMed reference number	23420130
Journal	Medline
Volume Number	49
Issue Number	24
Alternate Webpage(s)	http://www.rsc.org/suppdata/cc/c3/c3cc38589b/c3cc38589b.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c3cc38589b
Journal	Chemical communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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