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The Effect of an Acute Bout of Exercise on Endothelial Function following Ischemic-Reperfusion Injury
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lawrence, Jennifer Lee |
| Copyright Year | 2011 |
| Abstract | iii Acknowledgments v List of Tables viii List of Figures ix List of Abbreviations x Introduction 1 1.1 Purpose of Study 4 1.2 Hypothesis 4 Literature Review 5 2.1 Mechanisms of Ischemic Reperfusion Injury 5 2.1.1 Reactive Oxygen Species (ROS) 6 2.1.2 Neutrophil Activation 7 2.1.3 Complement Activation 8 2.2 Ischemic Preconditioning (IPC) 9 2.3 Remote Ischemic Preconditioning (RIPC) 10 2.4 Exercise Induced Cardioprotection 11 2.5 Exercise and Flow-Mediated Dilation (FMD) 13 Methods 16 3.1 Subjects 16 3.2 Experimental Design 16 3.2.1 Ischemic-Reperfusion Injury Protocol – Control (IRI) 17 3.2.2 Exercise Protocol – Control (EXER) 18 3.2.3 Exercise Preconditioning Protocol (EXER/IRI) 19 3.2.4 Flow-Mediated Dilation (FMD) 20 3.3 Data Analysis 20 vii 3.4 Statistical Analysis 21 Results 22 4.1 Brachial Artery Diameter Responses to Ischemic-Reperfusion Injury and Exercise ......... 22 4.2 FMD Responses of the Brachial Artery to Ischemic-Reperfusion Injury and Exercise ..... 23 4.3 Brachial Artery Blood Flow and Shear Stress Responses to Ischemic-Reperfusion Injury and Exercise 24 4.4 FMD/Shear Stress Responses to Ischemic-Reperfusion Injury and Exercise 24 Discussion 36 5.1 Limitations 40 5.2 Conclusion(s) 41 5.3 Future Directions 42 References 45 Appendix A 52 Appendix B 59 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://etd.ohiolink.edu/!etd.send_file?accession=toledo1313417778&disposition=attachment |
| Alternate Webpage(s) | https://utdr.utoledo.edu/cgi/viewcontent.cgi?article=1644&context=theses-dissertations&httpsredir=1&referer= |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
