NDLI: Heterogeneity of transport systems for L-glutamine in mouse mammary gland.

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Heterogeneity of transport systems for L-glutamine in mouse mammary gland.

Content Provider	Semantic Scholar
Author	Sharma, R. M. Kansal, Vinod Kumar
Copyright Year	2001
Abstract	The characteristics of the transport systems of L-glutamine in lactating mouse mammary gland have been studied. L-glutamine uptake was mediated by three Na+-dependent and one Na+-independent systems. The 2-(methylamino)isobutyric acid-sensitive component of Na+-dependent uptake exhibited the usual characteristics of system A. The other two Na+-dependent systems, which we have named BCI(-)-dependent and BCl(-)-independent, are the new systems identified. These are broad specificity systems and were discriminated on the basis of inhibition analysis, Cl- dependency and the effect of preloading mammary tissue with amino acids. While L-aspargine inhibited the uptake of L-glutamine via both these broad specificity systems, L-homoserine inhibited the uptake of L-glutamine via only BCl(-)-dependent system. The uptake of L-glutamine via the BCl(-)-independent system was upregulated by preloading mammary tissue with L-serine, while BCl(-)-dependent system was unaffected. The Na+-independent uptake of L-glutamine was inhibited by 2-aminobicyclo-(2,2,1)heptane carboxylic acid and other neutral amino acids, and identified as the system L.
File Format	PDF HTM / HTML
PubMed reference number	11811619
Journal	Medline
Volume Number	38
Issue Number	4
Alternate Webpage(s)	http://nopr.niscair.res.in/bitstream/123456789/15300/1/IJBB%2038(4)%20241-248.pdf
Journal	Indian journal of biochemistry & biophysics
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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