NDLI: Serotonin 5-HT Receptor Currents in the Healthy Rodent Prefrontal Cortex and in a Model of Affective Disorders

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Serotonin 5-HT Receptor Currents in the Healthy Rodent Prefrontal Cortex and in a Model of Affective Disorders

Content Provider	Semantic Scholar
Author	Goodfellow, Nathalie M.
Copyright Year	2013
Abstract	Affective disorders represent one of the greatest global burdens of disease. Work in patients with affective disorders demonstrates that serotonin (5-HT) signaling within the prefrontal cortex, particularly at the level of the 5-HT receptors, plays an integral role in both the pathology and treatment of these diseases. Surprisingly, the characterization of the prefrontal 5HT receptors under both healthy and pathological conditions remains incomplete. The technique of whole cell electrophysiological recording provides an unparalleled tool for investigating the functional effects of these 5-HT receptors on neurons in acute prefrontal cortical slices. The objectives of my thesis were to delve deeper into the 5-HT receptor subtypes that modulate the prefrontal cortex in the healthy control rodents and to examine how this modulation was disrupted in a rodent model of affective disorders. In work from healthy control rodents, I examined two prefrontal 5-HT receptor-mediated currents. I show for the first time the presence of the 5-HT1A receptor during the early postnatal period, a critical developmental window during which this receptor programs adult anxiety behaviors. In adulthood, I characterized an inhibitory current mediated by the 5-ht5A receptor; findings that will permit the classification of this receptor within the 5-HT receptor family.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://tspace.library.utoronto.ca/bitstream/1807/35831/7/Goodfellow_Nathalie_M_201306_PhD_thesis.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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