Potent antinociceptive effects of clonidine systemically administered in an experimental model of clinical pain, the arthritic rat

Content Provider	Semantic Scholar
Author	Kayser, Valérie Guilbaud, Giséle Besson, J. M.
Copyright Year	1992
Abstract	The effects of various doses of the alpha-2 adrenoceptor agonist clonidine administered systemically (30, 50 and 100 micrograms/kg i.v.), were investigated on the vocalization threshold to paw pressure in normal rats and in rats with Freund's adjuvant-induced arthritis. Previous results have suggested that there is an increase in the activity of the bulbospinal noradrenergic systems in these arthritic animals. In the present study, clonidine led to significant antinociceptive effects in both groups of rats. Clonidine was found to be highly effective in arthritic animals, even at the lower concentration: the elevation in threshold produced by 30 micrograms/kg i.v. was 160% in arthritic vs. 124% in normal rats. The effects of clonidine were prevented dose-dependently by pretreatment with yohimbine or idazoxan 250 to 1000 micrograms/kg i.v., in the two groups of rats, indicating clearly that the dose-dependent effects of i.v. clonidine are mediated by alpha-2 adrenoceptors.
Starting Page	7
Ending Page	13
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(92)91255-D
PubMed reference number	1360867
Journal	Medline
Volume Number	593
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/000689939291255D
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/000689939291255D?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2892%2991255-D
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article