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Synthesis and biological evaluation of new 1-(4,6-dimethylpyrimidin-2-yl)-1′-aryl/heteroaryl- 3,3′-dimethyl-(4,5′-bipyrazol)-5-ols as antimicrobial agents
| Content Provider | Semantic Scholar |
|---|---|
| Author | Aggarwal, Ranjana Rani, Chinu Sharma, Chetan Aneja, K. R. |
| Copyright Year | 2013 |
| Abstract | Hydroxy-3-methyl-1-(4,6-dimethylpyrimidin-2-yl)pyrazol-4-yl-1,3-butanedione 4, obtained by the rearrangement of 2-(4,6-dimethylpyrimidin-2-yl)-1-(1-(4-hydroxy-6-methylpyran- 2-one-3-yl)ethylidene)hydrazine 3, afforded 1-(4,6-dimethylpyrimidin-2-yl)-1'-aryl/heteroaryl- 3,3'-dimethyl-(4,5'-bipyrazol)-5-ols (6) in excellent yields after treatment with various aryl/ heteroaryl hydrazines. The structures of the compounds were established by nuclear magnetic resonance ( 1 H and 13 C), infrared, and mass spectral data, and by elemental analysis. All the compounds synthesized were screened for their antibacterial activity against two Gram- positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa), and their antifungal activity against two yeasts (Candida albicans and Saccharomyces cerevisiae). |
| Starting Page | 13 |
| Ending Page | 22 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.2147/ROC.S38674 |
| Alternate Webpage(s) | https://www.dovepress.com/getfile.php?fileID=15702 |
| Alternate Webpage(s) | https://doi.org/10.2147/ROC.S38674 |
| Volume Number | 3 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
