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Postconcussional disorder and PTSD symptoms of military-related traumatic brain injury associated with compromised neurocircuitry.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yeh, P. Wang, Binquan Oakes, Terrence R. French, Louis M. Pan, Hai Graner, John L. Liu, Wei Riedy, Gerard |
| Copyright Year | 2014 |
| Abstract | Traumatic brain injury (TBI) is a common combat injury, often through explosive blast, and produces heterogeneous brain changes due to various mechanisms of injury. It is unclear whether the vulnerability of white matter differs between blast and impact injury, and the consequences of microstructural changes on neuropsychological function are poorly understood in military TBI patients. Diffusion tensor imaging (DTI) techniques were used to assess the neurocircuitry in 37 U.S. service members (29 mild, 7 moderate, 1 severe; 17 blast and 20 nonblast), who sustained a TBI while deployed, compared to 14 nondeployed, military controls. High-dimensional deformable registration of MRI diffusion tensor data was followed by fiber tracking and tract-specific analysis along with region-of-interest analysis. DTI results were examined in relation to post-concussion and post-traumatic stress disorder (PTSD) symptoms. The most prominent white matter microstructural injury for both blast and nonblast patients was in the frontal fibers within the fronto-striatal (corona radiata, internal capsule) and fronto-limbic circuits (fornix, cingulum), the fronto-parieto-occipital association fibers, in brainstem fibers, and in callosal fibers. Subcortical superior-inferiorly oriented tracts were more vulnerable to blast injury than nonblast injury, while direct impact force had more detrimental effects on anterior-posteriorly oriented tracts, which tended to cause heterogeneous left and right hemispheric asymmetries of white matter connectivity. The tractography using diffusion anisotropy deficits revealed the cortico-striatal-thalamic-cerebellar-cortical (CSTCC) networks, where increased post-concussion and PTSD symptoms were associated with low fractional anisotropy in the major nodes of compromised CSTCC neurocircuitry, and the consequences on cognitive function were explored as well. |
| Starting Page | 299 |
| Ending Page | 308 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.safetylit.org/citations/ild_request_form.php?article_id=citjournalarticle_413639_27 |
| PubMed reference number | 24038816v1 |
| Alternate Webpage(s) | https://doi.org/10.1002/hbm.22358 |
| DOI | 10.1002/hbm.22358 |
| Journal | Human brain mapping |
| Volume Number | 35 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Attention deficit hyperactivity disorder Binswanger Disease Blast Injuries Brain Concussion Brain Injuries Brain Stem Brain fornix Cerebral cortex Cumulative Trauma Disorders Diffusion Anisotropy Diffusion Tensor Imaging Genetic Heterogeneity Internal capsule of brain Mood Disorders Patients Post-Traumatic Stress Disorder Stress Disorders, Traumatic Thalamic structure Tissue fiber Traumatic Brain Injury White matter dinoflagellate cingulum |
| Content Type | Text |
| Resource Type | Article |
