Vitamin D and adipogenesis: new molecular insights.

Content Provider	Semantic Scholar
Author	Wood, Richard Joseph
Copyright Year	2008
Abstract	The focus of the current review is to highlight some new insights into the molecular mechanism by which vitamin D, a potentially nutritionally modulated factor, influences adipogenesis. Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte. The latter action may reflect a vitamin D-induced decrease in endogenous PPAR gamma ligand availability and a competition between VDR and PPAR gamma for a limiting amount of retinoid X receptor (RXR), a common heterodimeric binding partner of both nuclear receptors.
Starting Page	75
Ending Page	78
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://naldc.nal.usda.gov/download/17952/PDF
Alternate Webpage(s)	http://li123-4.members.linode.com/files/Vitamin%20D%20and%20adipogenesis:%20new%20molecular%20insights.pdf
PubMed reference number	18254883v1
Alternate Webpage(s)	https://doi.org/10.1111/j.1753-4887.2007.00004.x
DOI	10.1111/j.1753-4887.2007.00004.x
Journal	Nutrition reviews
Volume Number	66
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	Adipocytes Adipogenesis Cell Culture Techniques Enhancer of transcription Inhibition Interleukin Receptor Common gamma Subunit PPAR gamma PPARG gene Peroxisome Proliferators Receptors, Nuclear Retinoid X Receptors Retinoids Trans-Activation, Genetic Vitamin A Vitamin D Vitamin D3 Receptor alpha-Mannosidosis ligands activity
Content Type	Text
Resource Type	Article