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Stollingsstoornissen bij patiënten met schedel-hersentrauma : een frequente en potentieel fatale combinatie
| Content Provider | Semantic Scholar |
|---|---|
| Author | Haagh, Wa. J. J. M. Pampus, Elisabeth C. Van Zutphen, Stefan W. A. M. Van Brink, Peter Rinze Gérard |
| Copyright Year | 2006 |
| Abstract | Abnormalities in blood coagulation are relatively common after traumatic brain injury (TBI) and play an important role in the morbidity and mortality after head injuries. - Exposure of tissue factor, which is abundantly present in brain tissue, is the initiator of the coagulation cascade and plays an important role in the pathogenesis ofcoagulopathy after TBI. - Coagulopathy after TBI is actually a manifestation of the disseminated intravascular coagulation (DIC) syndrome. - The interplay between hypothermia, acidosis and progressive coagulopathy, referred to as the 'lethal triad', results in high mortality. This necessitates damage control in the treatment of such TBI patients. - Repeated laboratory evaluation of the coagulation parameters in TBI patients is indicated, even if the initial values are normal. - The DIC score, a combination of frequently used coagulation parameters, is not only a measure of the coagulopathy but can also predict the outcome and prognosis following TBI. - Primary and secondary prevention of coagulopathy together with timely and effective intervention are the most important elements in the treatment of coagulation disorders. Nevertheless, the risk of death remains high. |
| Starting Page | 2530 |
| Ending Page | 2535 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Volume Number | 150 |
| Alternate Webpage(s) | https://www.ntvg.nl/system/files/publications/2006125300001a.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
