NDLI: Advanced Survival in Patients with Multiple Irradiations for Brain Melanoma Metastases and Associated Abscopal Effect

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Advanced Survival in Patients with Multiple Irradiations for Brain Melanoma Metastases and Associated Abscopal Effect

Content Provider	Semantic Scholar
Author	Galkin, Mikhail V. Golanov, Andrey Vetlova, Elena Banov, Sergey M. Kostjuchenko, Valery
Copyright Year	2018
Abstract	Brain metastases are often detected in melanoma patients. Central nervous system (CNS) involvement is usually associated with poor prognosis. We describe a case of a female patient with multiple melanoma brain metastases who survived for 49 months after detection of CNS involvement and the first radiosurgery. She underwent several courses of irradiation (five radiosurgeries, stereotactic hypofractionated radiotherapy, and whole brain radiotherapy), chemotherapy (started in 12 months after the first radiosurgery), and targeted therapy (started 30 months after the first radiosurgery). The clear abscopal effect in the form of disappearance of intradermal lesions was observed after the second radiosurgery without any systemic treatment. We believe that the application of combination of different treatment modalities can significantly prolong survival in certain patients with melanoma brain metastases, and can be recommended even in case of poor prognosis. Categories: Radiation Oncology, Neurosurgery, Oncology
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://assets.cureus.com/uploads/case_report/pdf/9953/1515810785-20180113-338-1ydn5nw.pdf
Language	English
Access Restriction	Open
Subject Keyword	CNS disorder Cessation of life Conflict (Psychology) Disclosure Forecast of outcome Forty Nine Metastatic malignant neoplasm to brain Neoplasm Metastasis Patients Radiosurgery Science of neurosurgery Therapeutic radiology procedure Uniform Resource Identifier While hypofractionated radiation therapy melanoma pediatric intracranial germ cell brain tumor stereotactic imaging
Content Type	Text
Resource Type	Article

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