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Metal-free addition of aliphatic carboxylic acids to cyanopropargyl alcohols: an access to new families of functionalized dihydrofurans and 3(2H)-furanones
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shemyakina, Olesya A. Volostnykh, Ol'ga G. Stepanov, Anton V. Ushakov, Igor A. Mal'kina, Anastasiya G. Apartsin, K. A. Kireeva, Viktoria V. Trofimov, Boris A. |
| Copyright Year | 2018 |
| Abstract | The metal-free Et3N-mediated addition of cyanopropargyl alcohols to aliphatic carboxylic acids provides for straightforward efficient access to 4-cyano-[(Z)-3-cyanomethylene]-2,3-dihydrofurans and 4-cyano-3(2H)furanones of pharmaceutical value. By comparison to analogous reactions using aromatic and heteroaromatic carboxylic acids, this synthesis is implemented under much milder conditions (room temperature vs. 100 °C and microwave assistance) to give essentially higher relative content of 2,3-dihydrofurans (2:1 assembly products). |
| Starting Page | 85 |
| Ending Page | 96 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.24820/ark.5550190.p010.569 |
| Volume Number | 2018 |
| Alternate Webpage(s) | https://www.arkat-usa.org/get-file/63754/ |
| Alternate Webpage(s) | https://www.arkat-usa.org/get-file/63565/ |
| Alternate Webpage(s) | http://www.arkat-usa.org/get-file/63572/ |
| Alternate Webpage(s) | https://doi.org/10.24820/ark.5550190.p010.569 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
