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Is there an association between IFN-γ +874A/T polymorphism and periodontitis susceptibility?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shi, Qisen Cai, Chuan Jie Xu, Juan Liu, Jinglong Liu, Hongchen Huo, N. X. |
| Copyright Year | 2017 |
| Abstract | BACKGROUND Interferon-γ (IFN-γ) is a key proinflammatory cytokine which plays a critical role in the pathogenesis and progression of periodontitis. The single nucleotide polymorphism of +874A/T in human IFN-γ gene can influence the secretion of IFN-γ and affect periodontitis susceptibility. However, the findings of published studies are inconsistent. Therefore, the goal of this meta-analysis is to investigate whether there is an association between IFN-γ +874A/T polymorphism and periodontitis susceptibility. METHODS PubMed and the Cochrane Library were searched for eligible clinical studies. The odds ratio (OR) and 95% confidence interval (CI) of each study were pooled to estimate the strength of association between +874A/T and periodontitis. Subgroup analyses were performed to explore whether particular characteristics of studies were related to the overall results. RESULTS Seven studies and a total of 1252 periodontitis patients and 1622 periodontitis-free control subjects were included. No difference was observed in genotype distribution and allele frequency between periodontitis patients and control (T vs A: OR = 1.01, 95% CI: 0.90-1.13, P = .878; TT vs AA: OR = 1.07, 95% CI: 0.87-1.32, P = .537; AT vs AA: OR = 1.00, 95% CI: 0.81-1.23, P = .996; TT+AT vs AA: OR = 1.00, 95% CI: 0.84-1.19, P = .990; TT vs AA+AT: OR = 1.03, 95% CI: 0.86-1.23, P = .733). Besides, the subgroup analysis based on ethnicity, type of periodontitis, and smoking status failed to identify significant differences in each model, either. CONCLUSIONS The results of this meta-analysis suggest that IFN-γ +874 A/T polymorphism may not contribute to periodontitis susceptibility. High quality and well-designed studies which combine genetic and other environmental risk factors are needed to validate this conclusion in the future. |
| Starting Page | 7 |
| Ending Page | 10 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28640144v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MD.0000000000007288 |
| DOI | 10.1097/MD.0000000000007288 |
| Journal | Medicine |
| Volume Number | 96 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Confidence Intervals Gene Frequency Interferon Type II Nucleotides Odds Ratio Patients Periodontitis Pooled Sample Scientific Publication Single Nucleotide Polymorphism Smoke Smoking Status Subgroup A Nepoviruses cytokine peginterferon alfa-2b |
| Content Type | Text |
| Resource Type | Article |
