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A straightforward synthetic access to symmetrical glycosyl disulfides and biological evaluation thereof.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adinolfi, Matteo Capasso, Domenica Gaetano, Sonia Di Iadonisi, Alfonso Leone, Loredana Pastore, Antonello |
| Copyright Year | 2011 |
| Abstract | Symmetrical glycosyl disulfides can be prepared within a few hours from per-O-acetylated precursors via a sequential approach entailing short reactions and no purification of any intermediate. The final thiolate-to-disulfide oxidation step is noticeably accelerated by low amounts of phenyl diselenide under air. Applicability of the strategy to non-saccharidic symmetrical alkyl disulfides has also been examined. A preliminary assay of the cytotoxic activity of symmetrical 1,1'- disulfides was performed on two human tumor cell lines, and a noteworthy activity was recorded for a range of these synthetic compounds. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c1ob05619k |
| PubMed reference number | 21792455 |
| Journal | Medline |
| Volume Number | 9 |
| Issue Number | 18 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/c1/c1ob05619k/c1ob05619k.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c1ob05619k |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
