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Targeted Drug Delivery to Breast Cancer using Polymeric Nanoparticle Micelles
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ho, Karyn S. |
| Copyright Year | 2012 |
| Abstract | Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable systemic toxicity and narrow therapeutic indices. To improve tumour accumulation, drug-loaded macromolecular assemblies have been designed to replace conventional surfactant-based formulations. Their nanoscale size enhances tumour accumulation via hyperpermeable vasculature and reduced lymphatic drainage. Incorporating targeting ligands introduces cell specificity through receptor-specific binding and uptake, enabling drugs to reach intracellular targets. In this work, the targeting properties of polymer nanoparticle micelles of poly(2-methyl-2-carboxytrimethylene carbonate-co-D,L-lactide)-graft-poly(ethylene glycol)furan (poly(TMCC-co-LA)-g-PEG) were verified using in vitro and in vivo models of breast |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://tspace.library.utoronto.ca/bitstream/1807/34054/3/Ho_Karyn_S_201211_PhD_thesis.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |