NDLI: Nanoparticle-aptamer bioconjugates for cancer targeting.

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Nanoparticle-aptamer bioconjugates for cancer targeting.

Content Provider	Semantic Scholar
Author	Farokhzad, Omid C. Karp, Jeffrey M. Langer, Robert S.
Copyright Year	2006
Abstract	The combination of targeted drug delivery and controlled-release technology may pave the road for more effective yet safer chemotherapeutic options for cancer therapy. Drug-encapsulated polymeric nanoparticle-aptamer bioconjugates represent an emerging technology that can facilitate the delivery of chemotherapeutics to primary and metastatic tumours. Aptamers are short nucleic acid molecules with binding properties and biochemical characteristics that may make them suitable for use as targeting molecules. The goal of this review is to summarise the key components that are required for creating effective cancer targeting nanoparticle-aptamer bioconjugates. The field of controlled release and the structure and properties of aptamers, as well as the criteria for constructing effective conjugates, will be discussed.
Starting Page	297
Ending Page	300
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.karplab.net/papers/Farokhzad_Exp_Opin_021006_Revised.pdf
PubMed reference number	16640493v1
Volume Number	3
Issue Number	3
Journal	Expert opinion on drug delivery
Language	English
Access Restriction	Open
Subject Keyword	Artificial nanoparticles Controlled Release Dosage Form Drug Delivery Systems Immunostimulating conjugate (antigen) Neoplasm Metastasis Neoplasms Nucleic Acids Polymers aptamer cellular targeting
Content Type	Text
Resource Type	Article

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