NDLI: Shortened outflow tract leads to altered cardiac looping after neural crest ablation.

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Shortened outflow tract leads to altered cardiac looping after neural crest ablation.

Content Provider	Semantic Scholar
Author	Yelbuz, Talât Mesud Waldo, Karen L. Kumiski, Donna H. Wolfe, Robert R. Leatherbury, Linda Kirby, M. J. L.
Copyright Year	2002
Abstract	BACKGROUND Congenital conotruncal malformations frequently involve dextroposed aorta. The pathogenesis of dextroposed aorta is not known but is thought to be due to abnormal looping and/or wedging of the outflow tract during early heart development. We examined the stage of cardiac looping in an experimental model of dextroposed aorta to determine the embryogenesis of this conotruncal malformation. METHODS AND RESULTS Hearts were examined from neural crest-ablated embryos by using videocinephotography, scanning electron microscopy, and histological sections. The inflow and outflow limbs of the looped cardiac tube were malpositioned with respect to each other, the inner curvature was diminished, and the outflow limb was straighter and displaced cranially in a manner consistent with diminished length. The altered length could be explained by a significant reduction in the number of cells added to the myocardium of the distal outflow tract from the secondary heart field. CONCLUSIONS The data are consistent with research showing that normal looping and wedging are essential for normal alignment of the aorta with the left ventricle. These processes are abnormal in neural crest-ablated embryos because of a failure of the outflow tract to lengthen by the addition of myocardial cells from the secondary heart field.
Starting Page	59
Ending Page	65
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/106/4/504.full.pdf?download=true
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/106/4/504.full.pdf
PubMed reference number	12135953v1
Volume Number	106
Issue Number	4
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Aorta Artificial cardiac pacemaker Congenital Abnormality Deformity Embryo Embryonic Development Heart Ventricle Left ventricular structure Limb structure Myocardium Neural Crest heart development heart looping
Content Type	Text
Resource Type	Article

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