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Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chételat, Gaël Desgranges, Béatrice Sayette, Vincent De La Viader, Fausto Berkouk, Karim Landeau, Brigitte Lalevée, Catherine Doze, François Le Dupuy, Bernard Hannequin, Didier Baron, Jean-Claude Eustache, Francis |
| Copyright Year | 2003 |
| Abstract | The present study aims to unravel, in the same study, both morphological and functional specific substrates of encoding versus retrieval deficits in patients with amnestic mild cognitive impairment (MCI). For this purpose, 21 highly screened MCI patients with isolated memory impairment, who attended a memory clinic and fulfilled operational criteria for MCI, underwent (i) two episodic memory subtests designed to assess preferentially either incidental encoding or retrieval capacity; (ii) a high-resolution T1-weighted volume MRI scan; and (iii) a resting state [18F]fluoro-2-deoxy-D-glucose PET study. Using statistical parametric mapping, positive correlations between memory scores on one hand, and grey matter density and normalized partial volume effect-corrected brain glucose utilization (ncCMRglc) on the other hand, were computed. Deficits in both encoding and retrieval were correlated with declines in hippocampal region grey matter density. The encoding subtest also correlated with hippocampal ncCMRglc, whereas the retrieval subtest correlated with the posterior cingulate area ncCMRglc only. The present findings highlight a distinction in the neural substrates of encoding and retrieval deficits in MCI. Furthermore, they unravel a partial dissociation between metabolic and structural correlates, suggesting distinct interpretations. Hippocampal atrophy was related to both encoding and retrieval deficits, possibly reflecting a direct effect on hippocampal functioning, as well as an indirect effect, through remote functional disruption, on posterior cingulate region synaptic function, respectively. |
| Starting Page | P36 |
| Ending Page | P36 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/brain/126/9/10.1093/brain/awg196/2/awg196.pdf?Expires=1492723790&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=ILZIXmytiyD0ZYY~uE7SjZiZnim-IQJoUKpnq4TLeotRJMxtUztQqUskiE3-7XWtLjmhca4PXWf5HWeHd1PkhZQrr40XSvmT7XL5nTHmKVvbGNZ4rfKvNY7l2QZsIWUy~0EO1J7BbxyGXiDRFGixPTiNStgIPlJtwLz4Z8DwmTE2ne7o8qjB5P3pES1o9kjD6TvyxGAbWAuxRlnbAsJWTK8j1u2OoYm6DNMD6Qrb8gFBe5vZEF57ixkWT1iKr~GX-Sl3BoWMoWYxVBGCaf-xKaKR1k6~DMucdvI0b~pVK-X~MeNRlWK~irpJGET-XjVsPZMZZTDpAH6s-41greql3w__ |
| Alternate Webpage(s) | http://brain.oxfordjournals.org/content/126/9/1955.full.pdf |
| PubMed reference number | 12821520v1 |
| Volume Number | 126 |
| Part | 9 |
| Journal | Brain : a journal of neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alzheimer's Disease Atrophic Cognition Disorders Elfacos OW 100 Glucose Metabolism Disorders Gray Matter Gyrus Cinguli Interpretation Process Juvenile Spinal Muscular Atrophy Magnetic Resonance Imaging Memory Disorders Metabolic Process, Cellular Mild cognitive disorder Patients Rest |
| Content Type | Text |
| Resource Type | Article |
