Loading...
Please wait, while we are loading the content...
Similar Documents
Hla-restricted Virus-specific Cytotoxic T-lymphocyte Responses to Live and Inactivated Influenza Vaccines
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ennis, Francis A. Riley, Diana Rook, Alain H. Potter, Christopher W. |
| Copyright Year | 1981 |
| Abstract | 36 young adult volunteers were given either virus, or inactivated surface-antigen influenza vaccine, containing influenza A (H1N1) antigen. Their peripheral-blood lymphocytes were analysed to determine whether cytotoxic T lymphocytes (CTL) were induced by these vaccines. All three vaccines induced HLA-restricted T-lymphocyte responses specific for influenza A virus. This CTL response was found in 28 of 30 volunteers who showed antibody responses and in 3 of 6 who did not develop antibodies. Virus infected target cells showing certain HLA antigens (A1, A9, and B8) were less susceptible to lysis by HLA-matched cytotoxic T effector cells than target cells which matched effectors at other HLA loci. |
| Starting Page | 887 |
| Ending Page | 891 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0140-6736(81)91389-1 |
| PubMed reference number | 6117682 |
| Journal | Medline |
| Volume Number | 318 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0140673681913891 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0140673681913891?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0140-6736%2881%2991389-1 |
| Journal | The Lancet |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
