Modulation of 7,12‐Dimethylbenz[a]anthracene‐induced Transmammary Carcinogenesis by Disulfiram and Butylated Hydroxyanisole in Mice

Content Provider	Semantic Scholar
Author	Rao, Araga Ramesha Hussain, Syed Perwez Jannu, Laxminarayana
Copyright Year	1989
Abstract	The individual as well as combined chemopreventive actions of disulfiram (DSF) and butylated hydroxyanisole (BHA) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced transmammary carcinogenesis in mice were examined. When nursing mothers receiving normal diet were treated with DMBA (1 mg/mouse) on days 6, 8 and 10 postpartum, the tumor incidence in their 50-week-old F1 progeny was 44.1%. When nursing mothers receiving 0.75% BHA diet, 0.5% DSF diet and 0.75% BHA + 0.5% DSF diet were similarly treated with DMBA, the tumor incidences in their 50-week-old F1 progeny were 14.7% (P less than 0.05), 12.5% (P less than 0.05) and 5.8% (P less than 0.01), respectively. It is concluded that diets containing BHA (0.75%) and DSF (0.5%), singly or in combination, can inhibit transmammary carcinogenesis in Swiss albino mice.
Starting Page	1171
Ending Page	1175
Page Count	5
File Format	PDF HTM / HTML
PubMed reference number	2516846v1
Volume Number	80
Journal	Japanese journal of cancer research : Gann
Language	English
Access Restriction	Open
Subject Keyword	9,10-Dimethyl-1,2-benzanthracene Butylated Hydroxyanisole Carcinogenesis Disulfiram Neoplasms
Content Type	Text
Resource Type	Article