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4-(2′-Pyridyl)imidazole as an artificial nucleobase in highly stabilizing Ag(I)-mediated base pairs
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schweizer, Kristina Koesters, J. Müller, Jens |
| Copyright Year | 2015 |
| Abstract | A new artificial nucleoside 2 comprising 4-(2′-pyridyl)imidazole as the nucleobase was devised and incorporated into a series of DNA oligonucleotide duplexes. The propensity of 2 to form metal-mediated homo and hetero base pairs was investigated in various 13mer and 26mer duplexes. The artificial nucleoside readily forms Ag(I)-mediated homo base pairs of the type 2–Ag(I)–2, in which the Ag(I) ion resides in a [2 + 2] coordination environment. In addition, the combination with the previously established imidazole nucleoside 1 leads to the formation of Ag(I)-mediated hetero base pairs (2–Ag(I)–1 and 1–Ag(I)–2) with a [2 + 1] coordination environment. With an increase in the melting temperature of ΔTm = 21.8 °C upon the formation of a Ag(I)-mediated base pair, the 2–Ag(I)–1 pair with the 13mer duplex is the most stabilizing Ag(I)-mediated base pair so far. Generally, the impact of the formation of a metal-mediated base pair on the properties of the DNA duplex was found to be significantly more prominent for shorter, intrinsically less stable duplexes. |
| Starting Page | 895 |
| Ending Page | 903 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00775-015-1274-2 |
| PubMed reference number | 26066856 |
| Journal | Medline |
| Volume Number | 20 |
| Alternate Webpage(s) | https://www.uni-muenster.de/imperia/md/content/anorganische_und_analytische_chemie/ak_mueller/mueller_jbic_2015_supp.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s00775-015-1274-2 |
| Journal | JBIC Journal of Biological Inorganic Chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
