Loading...
Please wait, while we are loading the content...
Similar Documents
Nalmefene decreases meal size, food and water intake and weight gain in Zucker rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mclaughlin, Carol L. Baile, Clifton A. |
| Copyright Year | 1983 |
| Abstract | Opioids are proposed to play a role in the control of food intake since administration of opioids increase food intake while administration of opioid antagonists decrease food intake. In these experiments responses to a new opioid antagonist, nalmefene, were measured in Zucker obese and lean rats. In obese male rats 1 mg/kg nalmefene decreased the size of the first meal after a 10-hr fast and decreased 14-hr food intake, indicating nalmefene is relatively long-acting. Administration of 1 mg/kg nalmefene daily for 7 days decreased average meal size and daily food intake and increased meal frequency; feeding responses on day 7 were similar to those on day 1, suggesting a lack of development of tolerance. Food and water intake and weight gain during a 3-week treatment period were decreased more in lean rats by low doses of nalmefene (up to 0.25 mg/kg) and more in obese rats by higher doses of nalmefene (0.50 mg/kg). These responses to a new opioid antagonist further support a possible role for opioids in the control of food intake. |
| Starting Page | 235 |
| Ending Page | 240 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(83)90045-X |
| PubMed reference number | 6634872 |
| Journal | Medline |
| Volume Number | 19 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/009130578390045X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/009130578390045X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2883%2990045-X |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
