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Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines Using a One-Pot Multibond Forming Process.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sharif, Salaheddin A. I. Calder, Ewen D. D. Delolo, Fábio G. Sutherland, Andrew |
| Copyright Year | 2016 |
| Abstract | Rapid access to allylic trichloroacetimidates bearing a 2-allylaminoaryl group from readily available 2-iodoanilines combined with a one-pot multibond forming process has allowed the efficient synthesis of a series of 5-amino-2,5-dihydro-1H-benzo[b]azepines. The potential of these compounds as synthetic building blocks was demonstrated by the preparation of a late-stage intermediate of the hyponatremia agent, mozavaptan. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/acs.joc.6b01357 |
| Alternate Webpage(s) | http://eprints.gla.ac.uk/121124/1/121124.pdf |
| PubMed reference number | 27414232 |
| Alternate Webpage(s) | https://doi.org/10.1021/acs.joc.6b01357 |
| Volume Number | 81 |
| Issue Number | 15 |
| Journal | The Journal of organic chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
